The Role of Reduced Phagocytosis in the Pathogenesis of Age-Related Macular Degeneration

Grant number: 1120095 | Funding period: 2017 - 2019

Completed

Abstract

Understanding the underlying mechanisms which lead to age-related macular degeneration (AMD) is critical if we are to ultimately develop novel treatments. We hypothesise that there is a defective ability to remove debris that accumulates in the retina as we age and this is a crucial step in the development of AMD. We will investigate this hypothesis in an AMD cohort and in a pre-clinical model where we will test the efficacy of an intervention that improves the ability to clear debris.

Related publications (8)

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Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

X Huang, C Fowler, Y Li, QX Li, J Sun, Y Pan, L Jin, KA Perez, C Dubois, YY Lim, C Drysdale, RL Rumble, HR Chinnery, CC Rowe, RN Martins, P Maruff, JD Doecke, Y Lin, AA Belaidi, KJ Barnham

2024-12-01

Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral mo..

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Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease

X Huang, Y Li, C Fowler, JD Doecke, YY Lim, C Drysdale, V Zhang, K Park, B Trounson, K Pertile, R Rumble, JW Pickering, RA Rissman, F Sarsoza, S Abdel-Latif, Y Lin, V Doré, V Villemagne, CC Rowe, J Fripp

2023-05-01

Introduction: Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk i..

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P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration

C Drysdale, K Park, KA Vessey, X Huang, E Caruso, Y Li, J Wong, JS Wiley, E Fletcher, RH Guymer, BJ Gu

2022-12-01

We have shown deficits in monocyte phagocytosis from patients with age-related macular degeneration (AMD). Cell membrane fluidity ..

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Identification of Leukocyte Surface P2X7 as a Biomarker Associated with Alzheimer’s Disease

Y Li, X Huang, C Fowler, YY Lim, SM Laws, N Faux, JD Doecke, B Trounson, K Pertile, R Rumble, V Doré, VL Villemagne, CC Rowe, JS Wiley, P Maruff, CL Masters, BJ Gu

2022-07-01

Alzheimer’s disease (AD) has shown altered immune responses in the periphery. We studied P2X7 (a proinflammatory receptor and a sc..

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Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

BJ Gu, X Huang, PK Avula, E Caruso, C Drysdale, KA Vessey, A Ou, C Fowler, TH Liu, Y Lin, A Horton, CL Masters, JS Wiley, RH Guymer, EL Fletcher

2021-03-17

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

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Failure of autophagy–lysosomal pathways in rod photoreceptors causes the early retinal degeneration phenotype observed in Cln6 nclf mice

P von Eisenhart-Rothe, A Grubman, U Greferath, LJ Fothergill, AI Jobling, JA Phipps, AR White, EL Fletcher, KA Vessey

2018-10-01

PURPOSE. Vision loss caused by photoreceptor death represents one of the first symptoms in neuronal ceroid lipofuscinosis, a condi..

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Nanosecond laser treatment for age-related macular degeneration does not induce focal vision loss or new vessel growth in the retina

KA Vessey, T Ho, AI Jobling, SA Mills, MX Tran, A Brandli, J Lam, RH Guymer, EL Fletcher

2018-02-01

PURPOSE. Subthreshold, nanosecond pulsed laser treatment shows promise as a treatment for age-related macular degeneration (AMD); ..

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Reduced Phagocytosis as a novel pathogenic mechanism in AMD pathogenesis

Emily Caruso, Ben Gu, Erica L Fletcher, Xin Huang, Pavan Avula, Kirstan Anne Vessey, James Saville Wiley, Robyn H Guymer

2017-06-01

University of Melbourne Researchers